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Bactozopran 1 gm vial

 

 

Bactozopran 1gm Vial

Cefozopran Hydrochloride is a new type of antibiotic of the fourth cephalosporin of injection  That Was Launched For The Treatment Of Severe Infections In Immune Compromised Patients Caused By Staphylococci And Enterococcus. While It Shows A Very Broad Antibacterial Spectrum Against Gram-Positive And Gram-Negative Organisms, It Is Particularly Potent Against S. Aureus, Enterococcus Faecalis, P. Aeruginosa, And Citrobacter Freundii. It Is Resistant To Hydrolysis By Most Chromosomal And Plasmid Mediated B-Lactamases And Is Reported To Be Active Against Respiratory, Urinary Tract, Obstetrical, Gynecological, Soft Tissue, And Surgical Infections...

Description

Cefozopran HCl is a fourth generation cephalosporin antibiotic and is freely soluble in DMSO and slightly soluble in water. Cefozopran Hydrochloride For Injection Occursas A White To Light Yellow, Powder Or Masses Cefozopran Hydrochloride For Injection Is A Preparation For Injection Which Is Dissolved Before Use.It Contains Not Less Than 90.0z And Not More Than115.0z Of The Labeled Potency Of Cefozopran(C19H17N9O5S2: 515.53)

Method Of Preparation:- Prepare Directely Under The Injections,With Cefozopran Hydrochloride.

The therapeutic effect of cefozopran a new semisynthetic parenteral cephalosporin, against experimental infections in mice was examined. Cefozopran was more effective than cefpiramide and was as effective as ceftazidime and cefpirome against acute respiratory tract infections caused by Klebsiella pneumoniae DT-S. In the model of chronic respiratory tract infection caused by K. pneumoniae 27, cefozopran was as effective as ceftazidime. The therapeutic effect of cefozopran against urinary tract infections caused by Pseudomonas aeruginosa P9 was superior to that of cefpirome and was equal to those of ceftazidime and cefclidin. In addition, cefozopran was more effective than ceftazidime and was as effective as flomoxef in a thigh muscle infection caused by methicillin-sensitive Staphylococcus aureus 308A-1. Against thigh muscle infections caused by methicillin-resistant S. aureus N133, cefozopran was the most effective agent. The potent therapeutic effect of cefozopran in those experimental infections in mice suggests that it would be effective against respiratory tract, urinary tract, and soft tissue infections caused by a variety of gram-positive and gram-negative bacteria in humans.

Mechanism

Similar to β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases.